Q&A: Are Paracetamol-based Painkillers Dangerous for Long-Term Health?

Paracetamol, also known as acetaminophen, is known to be acutely toxic to liver cells (i.e. - “hepatotoxic”). If you take too much at once, you can cause serious and even fatal damage to your liver. Taking the recommended amount of paracetamol only on infrequent occasions has not been clearly associated with adverse long term health consequences.

You should seriously consider taking antioxidant supplements to support your liver if you are also consuming things that hurt it. Milk thistle (standardized for high silymarin content, at least 80%) is a gold standard herb for protecting the liver from paracetamol poisoning. N-acetyl-cysteine (NAC) is another supplement that helps protect the liver (and kidneys) by indirectly increasing glutathione - one of the main chemicals responsible for helping our body process drugs. Both supplements are very commonly used to protect people from paracetamol (i.e. - Tylenol or acetaminophen) overdose as well as alcohol poisoning.

Milk thistle (University of Maryland Medical Center Database)
Cysteine (N-Acetyl-Cysteine, University of Maryland Medical Center Database)
The Little-Known Dangers of Acetaminophen (Life Extension Article)

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